*All Times Shown are in Eastern Daylight Time*

8:45 am Join our virtual coffee chat room to kick off conversation with your fellow integrins peers!

9:00 am Chair’s Opening Remarks

Integrin Innovation in Drug Discovery & Development

9:15 am Keynote: Targeting Integrin Tethering of Airway Smooth Muscle to Treat Exaggerated Airway Narrowing

  • Dean Sheppard Chief of Pulmonary, Critical Care, Allergy & Sleep & Director of Lung Biology Center, University of California, San Francisco

Synopsis

  • Current and emerging treatments for asthma target actin-myosin contraction or upstream inflammatory mediators
  • To narrow the conducting airways, contracting airway smooth muscle must be tightly tethered to the underlying ECM
  • Inhibition of integrins on airway smooth muscle cells can dramatically reduce airway narrowing and enhance the effects of existing brochodilators

9:45 am Integrins as Novel Targets in the Treatment of Severe Bloodstream Infection & Sepsis

  • Steve Kerrigan Head, Cardiovascular Infection Research Group & Chief Scientific Officer, RCSI University of Medicine and Health Sciences & Inthelia Therapeutics

Synopsis

  • Establish what is known about the molecular interactions that drive the sustained and excessive response in sepsis
  • Discuss the critical role of integrins in driving the early response in sepsis
  • Discuss the results of a preclinical trial targeting integrins to disrupt the early signals that drive systemic dysregulation during sepsis

10:15 am PLN-74809, an Oral, Dual-Selective Inhibitor of αvβ6 & αvβ1 Integrins for the Treatment of IPF & PSC

  • Scott Turner Vice President of Translational Sciences, Pliant Therapeutics

10:45 am Speed Networking Break

Synopsis

Take part in this ice-breaker session where our platform will pair you up with a fellow colleague to spark a conversation to expand your scientific and integrin network!

Taking Back Control – Tightening Your Targeted Regulation of Integrins

11:10 am Targeting RGD-Binding Integrins as an Integrative Therapy for Diabetic Retinopathy & Neovascular Age-Related Macular Degeneration

Synopsis

  • The pathophysiological role of RGD-binding integrins in complex multifactoral retinal disorders
  • Evidence from clinic supporting RGD integrin inhibition as treatment for retinal diseases
  • Future potential for limiting the progression of these diseases

11:40 am Targeting αvβ8 Integrins for Innovative Immunotherapies in Cancer

  • Julien Marie Dean of the Tumor Escape Resistance & Immunity Department, Inserm

Synopsis

  • αvβ8 integrin contributes to the activation of TGFβ, a key immunosuppressive cytokine impairing T cells anti-tumor response
  • Preventing TGFβ activation in the tumor micro-environment constitutes an innovative immunotherapy
  • We identified cellular mechanisms of the action of αvβ8 integrin that can be targeted both in mouse and patient tumors

12:10 pm Understanding the Mechanism Behind Vimentin’s Control on the β1 Integrin Signaling Systems

Synopsis

  • Vimentin filaments control the β1 integrin signaling systems that regulate the attachment of cells to collagen, the formation of cell extensions, and cell migration through soft connective tissues
  • Vimentin tunes cell migration through collagen by acting as an adaptor protein for focal adhesion proteins, thereby regulating the proteins that mediate cell attachment to collagen
  • Detection of the mechanism by which vimentin controls the signaling system that controls β1 integrin adhesion to collagen, the formation of cell extensions, and cell migration through soft connective tissue might provide novel drug targets for studies of matrix remodeling and fibrosis

12:40 pm Roundtable Discussion: Integrin-Targeted Approaches: The Challenges & Benefits of Using Small Molecules, Antibodies & Oligonucleotides

Synopsis

Turn your cameras on and join your peers in an open discussion on the challenges and benefits of using small molecules, antibodies and oligonucleotides as integrin inhibitors or activators.

1:10 pm Networking Lunch

Synopsis

Grab a bite and join our networking lunch room to continue the scientific discussion, and use this opportunity to ask fellow colleagues your burning questions!

Uncovering the Therapeutic Potential of Integrins

2:10 pm Low Dose Integrin Targeting & Enhancing Cancer Therapy

Synopsis

  • Low dose b3-integrin targeting
  • Cancer therapy combinations
  • Reducing toxicity and enhancing efficacy

2:40 pm Integrin Modulation & Retinal Vascular Disease

  • Peter Kaiser Professor of Ophthalmology , Cleveland Clinic

Synopsis

  • Discuss the role of integrins and retinal vascular disease
  • Explore the current state of clinical trials using integrin antagonism and retinal vascular disease
  • Future directions for integrin modulation and retinal vascular disease

3:10 pm Scientific Poster Session

Synopsis

Join this interactive poster session where you can see the latest data from fellow scientists. Grab an afternoon refreshment and take part in this poster session or be part of the Q&A!

You’re registered but haven’t submitted your poster abstract yet? Do so here!

3:20 pm Afternoon Networking Break

Synopsis

Grab a cup of coffee and take a chance to explore the networking opportunities: make new connections via speed networking or join in the conversation in our networking chat room.

Dissecting the Biology & Chemistry of Integrins

3:50 pm Integrins are Targeted by SARS-CoV-2 Cell Attachment Modulating Endocytosis & Autophagy in Host Cells

Synopsis

• Spike protein of SARS-CoV-2 contains an integrin binding motif that was shown to be functional in an in vitro setting
• Targeted integrins contain short linear motifs in their cytoplasmic tails through which they can interact with host endocytosis and autophagy
• SARS-CoV-2 hijacks at least two other receptors in addition to integrins, which can propagate overlapping signals in the host cell
• Understanding the hijacking processes of cooperatively functioning receptors opens up possibilities of host directed therapies against viral infections

4:20 pm Integrin Alpha X Regulates Hematopoietic Stem & Progenitor Cells Under Stress

  • Koichi Yuki Senior Associate in Cardiac Anesthesia , Boston Children’s Hospital

Synopsis

• Alpha X is expressed on short-term hematopoietic stem cells and multipoint progenitor cells
• Alpha X plays a role in the homeostasis of hematopoietic stem and progenitor cells under stress
• Alpha X is involved in proliferation and apoptosis

4:50 pm Chair’s Closing Remarks & End of Day One